{"id":305,"date":"2015-04-30T19:09:12","date_gmt":"2015-04-30T19:09:12","guid":{"rendered":"http:\/\/medicinaveterinaria.ulpgc.es\/?p=305"},"modified":"2016-03-13T19:12:19","modified_gmt":"2016-03-13T19:12:19","slug":"acute-phase-protein-response-in-heartworm-infected-dogs-after-adulticide-treatment","status":"publish","type":"post","link":"https:\/\/medicinaveterinaria.ulpgc.es\/?p=305","title":{"rendered":"Acute phase protein response in heartworm-infected dogs after adulticide treatment."},"content":{"rendered":"<p class=\"details\" style=\"margin: 0cm; margin-bottom: .0001pt; background: white;\"><span style=\"color: black;\">Vet Parasitol. 2015 Apr 30;209(3-4):197-201.\u00a0<\/span><span style=\"font-size: 11.0pt; color: black;\">doi: 10.1016\/j.vetpar.2015.02.036. Epub 2015 Mar 12.<\/span><\/p>\n<p class=\"details\" style=\"margin: 0cm; margin-bottom: .0001pt; background: white;\"><span style=\"color: black;\">M\u00e9ndez JC, Carret\u00f3n E, Mart\u00ednez-Subiela S, Tvarijonaviciute A, Cer\u00f3n JJ, Montoya-Alonso JA<\/span><\/p>\n<h3>Abstract<\/h3>\n<p>During the adulticide treatment of Dirofilaria immitis the worms die releasing fragments of parasites and causing pulmonary thromboembolisms which could exacerbate the clinical condition. To determine the utility of <span class=\"highlight\">acute phase proteins<\/span> (APPs) to monitor the progression of the treatment, different positive [C-reactive <span class=\"highlight\">protein<\/span> (CRP), haptoglobin (hp)] and negative [albumin, paraoxonase-1(PON-1)] APPs were measured in 15 <span class=\"highlight\">heartworm-infected<\/span> <span class=\"highlight\">dogs<\/span> (5 with high and 10 with low parasite burden) following adulticide treatment. The results showed increased concentrations of CRP, decreased concentrations of haptoglobin and PON-1 in infected <span class=\"highlight\">dogs<\/span> before starting the treatment. Progressive but not significant increases were observed in PON-1 activity and albumin concentration along the treatment. <span class=\"highlight\">After<\/span> the treatment with doxycycline and ivermectine a decrease in CRP and Hp levels was experienced, which could reflect a reduction of the vascular inflammation caused by the elimination of Wolbachia and reduction of microfilariae. Fifteen days <span class=\"highlight\">after<\/span> the first melarsomine injection, marked increases in CRP and Hp were observed, which could be due to pulmonary inflammation and thromboembolism caused by the post-adulticide death of the worms. This increase was greater in <span class=\"highlight\">dogs<\/span> with high parasite burden. As the pathology disappeared, there was an improvement in the concentrations of CRP and Hp, returning into reference values in <span class=\"highlight\">dogs<\/span> with low parasite burden at the end of the treatment. The measurement of CRP and Hp could be a resource of support to evaluate the magnitude of the post-adulticide complications during the adulticide treatment of D. immitis.<\/p>\n<a class=\" enigma_btn_blue enigma_btn_large  \" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25801227\" target=\"\">Enlace a PubMed<\/a>\n","protected":false},"excerpt":{"rendered":"<p>Vet Parasitol. 2015 Apr 30;209(3-4):197-201.\u00a0doi: 10.1016\/j.vetpar.2015.02.036. Epub 2015 Mar 12. M\u00e9ndez JC, Carret\u00f3n E, Mart\u00ednez-Subiela S, Tvarijonaviciute A, Cer\u00f3n JJ, Montoya-Alonso JA Abstract During the adulticide treatment of Dirofilaria immitis the worms die releasing fragments of parasites and causing pulmonary thromboembolisms which could exacerbate the clinical condition. To determine the utility of acute phase proteins<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13,8,9],"tags":[],"_links":{"self":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/305"}],"collection":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=305"}],"version-history":[{"count":2,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/305\/revisions"}],"predecessor-version":[{"id":307,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/305\/revisions\/307"}],"wp:attachment":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}