{"id":563,"date":"2016-02-17T12:39:41","date_gmt":"2016-02-17T12:39:41","guid":{"rendered":"http:\/\/medicinaveterinaria.ulpgc.es\/?p=563"},"modified":"2016-06-17T12:47:10","modified_gmt":"2016-06-17T12:47:10","slug":"serum-collagen-type-ii-cleavage-epitope-and-serum-hyaluronic-acid-as-biomarkers-for-treatment-monitoring-of-dogs-with-hip-osteoarthritis","status":"publish","type":"post","link":"https:\/\/medicinaveterinaria.ulpgc.es\/?p=563","title":{"rendered":"Serum collagen type II cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring of dogs with hip osteoarthritis"},"content":{"rendered":"<div id=\"profilelayout\">\n<div id=\"profileleftside\">\n<div id=\"profileleftinside\">\n<div class=\"svBigBox sdBase\">\n<div class=\"paddingT5 paddingB5\">\n<div class=\"sourceCrossMain\">\n<div class=\"sourceTitle sourceTitleWidth\"><a title=\"Go to the information page for this source\" href=\"https:\/\/www.scopus.com\/source\/sourceInfo.uri?sourceId=10600153309&amp;origin=recordpage\">PLoS ONE<\/a><\/div>\n<\/div>\n<div class=\"volumeInfo\">Volume 11, Issue 2, February 2016, Article number\u00a0e0149472<\/div>\n<div>Vilar, J.M., Rubio, M., Spinella, G., Cuervo, B., Sopena, J., Cugat, R., Garcia-Balletb, M., Dominguez, J.M., Granados, M., Tvarijonaviciute, A., Ceron, J.J., Carrillo, J.M.<\/div>\n<\/div>\n<div>\n<h2 class=\"subTitle paddingT7 paddingB10\">Abstract<\/h2>\n<p id=\"recordAbs\" class=\"marginB3\" align=\"justify\">The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs. \u00a9 2016 Vilar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.<\/p>\n<\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PLoS ONE Volume 11, Issue 2, February 2016, Article number\u00a0e0149472 Vilar, J.M., Rubio, M., Spinella, G., Cuervo, B., Sopena, J., Cugat, R., Garcia-Balletb, M., Dominguez, J.M., Granados, M., Tvarijonaviciute, A., Ceron, J.J., Carrillo, J.M. Abstract The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic<\/p>\n","protected":false},"author":1,"featured_media":565,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[23],"tags":[],"_links":{"self":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/563"}],"collection":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=563"}],"version-history":[{"count":1,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/563\/revisions"}],"predecessor-version":[{"id":564,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/563\/revisions\/564"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/media\/565"}],"wp:attachment":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}