{"id":591,"date":"2016-08-10T16:54:32","date_gmt":"2016-08-10T16:54:32","guid":{"rendered":"http:\/\/medicinaveterinaria.ulpgc.es\/?p=591"},"modified":"2016-09-18T17:02:23","modified_gmt":"2016-09-18T17:02:23","slug":"therapeutic-doses-of-plasma-rich-in-growth-factors-cannot-provoke-cancer-by-means-of-the-igf-1-pathway-or-inflammation-in-dogs","status":"publish","type":"post","link":"https:\/\/medicinaveterinaria.ulpgc.es\/?p=591","title":{"rendered":"Therapeutic doses of plasma rich in growth factors cannot provoke cancer by means of the IGF-1 pathway or inflammation in dogs"},"content":{"rendered":"<p>Vilar, J.M.,\u00a0Dami\u00e1, E.,\u00a0Rubio, M.,\u00a0Santana, A.,\u00a0Sopena, J., Ceron, J.,<br \/>\nTvarijonaviciute, A.,\u00a0Cugat, R.,\u00a0Carrillo, J.M.<\/p>\n<h2>Abstract<\/h2>\n<p id=\"recordAbs\" class=\"marginB3\" align=\"justify\">A potential relationship between an increased risk of cancer and increased levels of serum insulin-like growth factor-1 (IGF-1), and presence of cancer and high levels of C-reactive protein (CRP) has been previously reported. This study evaluated the influence of a single intramuscular injection of plasma rich in growth factors (PRGF) on serum concentrations of IGF-1 and CRP in dogs. Two groups of eight healthy beagles were injected with two different doses of PRGF in lumbar muscles. For each treatment, IGF-1 and CRP were analysed from blood samples obtained at baseline and the following three days post injection. No differences were found when IGF-1 and CRP were compared among times in the two protocols. Local application of PRGF at clinical doses did not cause significant changes in systemic concentrations of IGF-1 or detectable inflammation. \u00a9 2016 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group<\/p>\n<a class=\" enigma_btn_blue enigma_btn_large  \" href=\"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/09712119.2016.1218888\" target=\"\">Article<\/a>\n","protected":false},"excerpt":{"rendered":"<p>Vilar, J.M.,\u00a0Dami\u00e1, E.,\u00a0Rubio, M.,\u00a0Santana, A.,\u00a0Sopena, J., Ceron, J., Tvarijonaviciute, A.,\u00a0Cugat, R.,\u00a0Carrillo, J.M. Abstract A potential relationship between an increased risk of cancer and increased levels of serum insulin-like growth factor-1 (IGF-1), and presence of cancer and high levels of C-reactive protein (CRP) has been previously reported. This study evaluated the influence of a single intramuscular<\/p>\n","protected":false},"author":1,"featured_media":595,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[13],"tags":[],"_links":{"self":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/591"}],"collection":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=591"}],"version-history":[{"count":2,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/591\/revisions"}],"predecessor-version":[{"id":594,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/posts\/591\/revisions\/594"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=\/wp\/v2\/media\/595"}],"wp:attachment":[{"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicinaveterinaria.ulpgc.es\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}